Without a trophy since 2008, Tottenham has seen one of its two realistic shots at silverware this season disappear already.

Davinson Sanchez was the only player who failed to score in a penalty shootout as Tottenham lost 5-3 to Fulham on spot kicks to get eliminated in the second round after a 1-1 draw in regulation on Tuesday.

Spurs have been knocked out before England’s top teams have even entered the competition. The Premier League clubs competing in Europe this season don’t play in the League Cup until the third round.

It’s the first time Tottenham has lost in the second round since an embarrassing defeat to lower-league Grimsby in 2005.

Micky van de Ven’s own-goal in the 19th minute put Fulham ahead before Brazil striker Richarlison headed in an equalizer in the 56th.

In the shootout, Sanchez — the Colombia center back who was the subject of criticism from some Tottenham fans last season — had his attempt saved by Fulham goalkeeper Marek Rodak off his team’s third penalty.

Kenny Tete converted the clinching spot kick for Fulham at Craven Cottage.

Tottenham, getting accustomed to life without Harry Kane following his move to Bayern Munich, now just has the Premier League and FA Cup to compete in this season, and the league looks a massive long shot for a team with a new manager in Ange Postecoglou.

Postecoglou might face some criticism, then, for fielding a weakened lineup against Fulham — Richarlison and Van de Ven were the only two players retained after Saturday’s 2-0 win against Bournemouth — despite the League Cup being one of the few opportunities for a trophy.

Five Premier League teams avoided upsets against lower-league opponents elsewhere Tuesday, with Brentford only getting past Newport County by winning a shootout 3-0. The game finished 1-1, with Newport equalizing in the sixth minute of stoppage time.

Crystal Palace came from 2-0 down to win 4-2 at second-tier Plymouth, with Jean-Philippe Mateta scoring a 22-minute hat trick. Palace scored three goals in a five-minute span from the 58th to take the lead.

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